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Reduced caloric intake is a significant contributor
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This occurs because semaglutide's appetite-suppressing effects reverse, gastric emptying returns to normal speed, and the metabolic adaptations that occur with weight loss (including reduced energy expenditure) persist
Its dual-action GIP/GLP-1 mechanism produced an average of about 21% weight reduction in clinical trials, a level of weight reduction not previously seen with medication alone
Both sRAGE forms are believed to be competitive inhibitors of RAGE
