In the STEP-1 trial, semaglutide 2.4 mg produced a total lean mass loss of 6.92 kg, which represented 13.2% of baseline lean mass
That said, physicians retain prescribing authority for compounded medications under state pharmacy law and the Drug Quality and Security Act
However, retatrutide is a first-in-class triple agonist (targeting GIP, GLP-1, and glucagon receptors simultaneously), which may lead to more cautious FDA review compared to drugs with established mechanisms
The 2.4 mg dose is the highest approved amount and is where most people experience their maximum weight loss benefit
According to the Centers for Disease Control and Prevention (CDC), it is one of the most commonly recommended over-the-counter medications for headache relief
By age 60, plasma concentrations drop to approximately 80 ng/mL