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The carboxylate group of carnitine forms a salt bridge with the guanidinium group of R471 (TM11), as well as a hydrogen bonding interaction with the hydroxyl of Y447 (TM10), both residues from the C-terminal bundle

Chem 405(8) , 2635-42, (2013) Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery

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PMID 10736350

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Cell Mol Gastroenterol Hepatol