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For the first time in the history of obesity medications we see weight loss efficacy of a magnitude that might raise concern about excessive loss of lean body tissue due to the initial pronounced reduction in energy intake and subsequent risk of protein deficiency

Meanwhile, existing treatments for other conditions could be repurposed for weight loss

Collection and preparation of plasma, liver, and kidney specimens for metabolomics Blood was obtained via cardiac puncture and centrifuged at 3000 g at 4 C for 10 min

doi: 10.1177/039463200301600103 153 RoyS.HalderM.RamprasadP.DasguptaS.SinghY.PalD

Rodriguez-Furlan, C

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