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( Table 2 )

The results were striking: 65% of patients in the combination group achieved a greater than 50% reduction in their neuropathy symptom scores, a statistically superior outcome compared to only 10.5% in the Benfotiamine-only group and 27.7% in the Lipoic Acid-only group

Synaptic impairment is thought to occur early in the neurodegenerative process across a range of pathologies and may result from a complex combination of pathologic mechanisms including toxic amyloid beta and tau oligomers (Gutierrez and Limon, 2022

Semaglutide, a popular medication marketed under names like Ozempic and Wegovy, has become a go-to treatment for weight loss and type 2 diabetes management

10 Thus, although our results suggest that GLP-1 secretion is not primarily regulated in a sleep-dependent manner in healthy men, the contribution of subtle changes in postprandial GLP-1 signaling to the deteriorating effect of sleep loss on glucose homeostasis and food intake regulation deserves a closer look in future investigations