Workowski KA, Bolan GA, Centers for Disease Control and Prevention
People with hypothyroidism or under thyroid hormone therapy should exercise special caution
During periods when participants used semaglutide, these risks were 42% lower compared with periods without GLP-1 treatment
The published human data is limited to topical skin applications and cosmetic endpoints
For example, induction of ferroptosis via GPX4 inhibition often triggers upregulation of ferroptosis suppressor protein 1 (FSP1)-mediated lipid peroxide detoxification, reducing long-term therapeutic efficacy (175, 176)
Kawamori D, Shirakawa J, Liew CW et al (2017) GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in IRKO mice