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Some domestic experts argue that the technique lacks high-quality long-term follow-up data, carries uncertain safety and long-term efficacy profiles, and may lead to severe complications such as liver failure and malnutrition when used in isolation

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Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MT, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF

First, it can impair the transport of long-chain fatty acids into the mitochondrial matrix, with subsequent decrease in -oxidation, acetyl-CoA and ATP production

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