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Grammas, P., Tripathy, D., Sanchez, A., Yin, X

There are two types of carnitine deficiency: Primary carnitine deficiency A genetic disorder Usually develops by five years of age Symptoms include Disease of the heart muscle (cardiomyopathy) Skeletal-muscle weakness Low blood sugar (hypoglycemia) Secondary carnitine deficiency Caused by other underlying conditions that decrease the amount of carnitine in the body that cause the body to: Increase the amount of carnitine excreted in urine Absorb less carnitine from food Chronic renal failure Use of certain antibiotics Certain medicines, such as valproate Liver disease Digestive disease that causes poor absorption Malnutrition Mitochondrial disease Certain metabolic disorders From Diet and Weight Loss Resources Image source: iStock Images

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Generally, for any given supplement ingredient, there will be (if you're lucky) just one or two forms of that ingredient capable of crossing the BBB and for carnitine, that form is ALCAR

Mitochondria are not only involved in the bioenergetics and bio-maintenance of various cellular functions but also involved in the modulating the innate immune system via controlling the ROS and RNS generation

Gillani SW et al