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As clinical data for both anti-PCSK9 antibodies and GLP-1 analogue molecules are widely available, we used PK-PD modelling to determine the appropriate potency at human GLP-1R for the fusion molecule that should deliver robust glucose control without inducing non-manageable GLP-1 driven adverse events at exposure levels able to efficiently neutralize PCSK9

N Engl J Med 1987;316:764-70

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