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J Am Coll Cardiol 1995;26:380-7

Just be sure to patch test if you are unsure about certain ingredients

Well-diffracting crystals were obtained after a few days in condition G8 of the Pi-PEG screen (Jena Bioscience), containing 34.3% (w/v) PEG 550 monomethyl ether and 2.9% (w/v) PEG 300

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However, this inactivation can allow for the accumulation of 4-OHE 2 , as 2-OHE 2 inhibits 4-OHE 2 methylation by COMT, but 4-OHE 2 does not inhibit 2-OH-E 2 methylation in return