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Some researchers believe that these substitutions confer increased potency, receptor interaction efficiency, and an extended period during which the peptide might remain active in a controlled research setting

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Together with the DNA (WHD) and histone-binding capability (PHD) of KAT6A itself, these chromatin adaptor proteins ensure secure recruitment of KAT6A to the chromatin, where the HAT domain can access and acetylate its histone lysine target(s)

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May 28 2022;14(11)doi:10.3390/nu14112256

Lancet 395, 10331034