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(That post-cake euphoria isnt as strong.) GLP-1s override the hedonic component of the brains reward system that part of the brain that wants us to eat food for the sole purpose of consuming something we like, says Hurtado Andrade

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Its understanding who will see improvements in blood sugar, heart health, liver disease and kidney function. Long-term questions still remain Hardaway says GLP-1 drugs are essentially supercharged versions of a naturally occurring hormone, and decades of neuroscience research show that receptors can adapt to prolonged stimulation

A narrative review published in the journal Nutrients found that patients on GLP-1 receptor agonists face measurable risks of deficiency in vitamin B12, vitamin D, iron, calcium, magnesium, and several B vitamins

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Furthermore, CNS GIPR KO mice have a lower body weight than control mice