Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, improve glycemic control and are associated with weight loss, but the impact of weight loss on major adverse cardiovascular events (MACE) when taking semaglutide is not fully understood
While GLP-1 therapies work through incretin pathways, cagrilintide activates amylin receptors located in key metabolic control centers of the brain[2]
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Improvements in cholesterol, triglycerides and blood pressure are encouraging surrogate measures, but surrogate improvement has not always translated into outcome benefit in drug development
Compounds like Retatrutide represent the next phase of incretin-based peptide investigation, where researchers are exploring whether broader receptor engagement can unlock more advanced metabolic responses