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In 2-year rat carcinogenicity studies referenced in the Increlex label, increased mammary and skin tumor incidence occurred at high IGF-1 exposure

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AD model mice suggested an increase in Hdac1/Hdac2, glycolysis/H4K12la/PKM2 signaling, and a decrease in Jmjd3, a histone H3K27me3 demethylase (Pan et al., 2022

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Youll be advised to keep your skin hydrated, avoid sun exposure, and use a broad-spectrum SPF daily