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Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy

Rather than replacing individual peptides, these combinations bring together complementary mechanisms associated with vascular biology, cellular migration, extracellular matrix remodeling, and connective tissue physiology

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Patients should discuss supplementation with their GP or pharmacist to ensure it is safe and appropriate for their individual circumstances

It changes whether the peptide reaches those tissues in the first place

The peptide GHK occurs naturally