When I teach interpretation of the medical literature to students, I remind them that if you think something sounds too good to be true, it probably is
This decline happens naturally with age, but obesity accelerates the process significantly
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Alterations in Vd resulting from reduced fat mass and alterations in clearance resulting from changes in CYP activity and GFR are key factors in determining pharmacokinetics
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GLP-1s have proven successful for many of these kids, but doctors who oppose their use fear that the drugs tendency to reduce calorie and nutritional intake may affect bone growth, brain development, and even puberty, according to the article