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A practical design principle is dual or sequential subcellular targeting, in which a mitochondria-enriched motif is combined with a second motif that biases accumulation at a partner compartment such as the ER, increasing the probability that payloads reside near contact zones where calcium, redox and lipid exchange are integrated

Chen and co-workers first presented the MnO 2 -based nanoagent with both Fenton metal ion delivery and GSH exhaustion capability (Figure 1E) (Lin et al., 2018)

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This sexual dimorphism primarily stems from sex-dependent metabolism

Voyvodic PL, Min D, Liu R, Williams E, Chitalia V, Dunn AK, Baker AB