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A 2022 study published in the Journal of Dietary Supplements adds another twist

This might lead to deficiency, more so with long-term use or high doses

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Lack of sleep also makes you hungrier, causes you to store more fat, and makes your body less sensitive to the hormone insulin, sabotaging attempts to lose weight and increasing your risk of developing type 2 diabetes or cardiovascular disease

We tested the translational relevance of our findings in mice by treating activated human ILC2s with melatonin and IKE

It should be noted that these parameters remained significantly different from what was observed in normoinsulinemic subjects (Table 2)