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Melanotan II acts as a non-selective agonist with nanomolar-range affinity at MC1R, MC3R, MC4R, and MC5R, with relative potencies varying by assay system but generally showing highest functional activity at MC1R and MC4R in cAMP accumulation assays using transfected cell lines

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Cardiac inflammation, fibrosis and hypertrophy are the main manifestations of myocardial dysfunction

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Chang JR, Koo E, Agron E, Hallak J, Clemons T, Azar D,

Taurine maintains glutathione levels for the detoxification of ROS and prevents oxidative stress on mitochondria