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The primary composite endpoint was the time from randomization to first occurrence of a major adverse cardiovascular event (MACE): cardiovascular death, non-fatal myocardial infarction or non-fatal stroke

People who could become pregnant should ask about product-specific label guidance and contraception considerations

[25] [26] NICE recommends GLP-1 receptor agonists as second- or third-line therapy for type 2 diabetes when metformin and other oral agents have not achieved adequate control

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References 1 GBD 2019 Diseases and Injuries Collaborators

Theory cannot substitute for dose-finding, interaction, and adverse-event data