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Additionally, stress-induced hormonal changes, characterized by an increase in cortisol levels, have been linked to the acceleration of premature greying by affecting melanocyte stem cells

it is recognized as a complex, multi-hormone metabolic disorder

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Moreover, in addition to showing the direct inhibition of GAPDH by oxidation, the authors demonstrated that its activity is further hindered by DHA-induced NAD + depletion, since GAPDH activity relies on the availability of NAD + as a co-substrate

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