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Also What about the other effects that can happen with Long term use

NicoteraPLeistMSingleBVolbrachtC Execution of Apoptosis: Converging or Diverging Pathways

Patients who remain at lower doses (2.55 mg) due to side effect concerns may not achieve optimal therapeutic benefit

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Athira Settles False Claims Act Athira Pharma settles for $4 million with the US Department of Justice related to NIH grants using compromised research data