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Methylcobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)

[11] In practice, the benefit of treating a true B deficiency in pregnancy, preventing anemia and neurological injury, is considered to far outweigh any theoretical risks, under the guidance of a healthcare professional

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In most food sources, B12 is bound to a protein molecule released by the metabolic activity of hydrochloric acid and other enzymes in the stomach

Hormone Research (2000) 5