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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)
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Townsend D, Tew K
Inhibitory effect of metformin and pyridoxamine in the formation of early, intermediate and advanced glycation end-products
Bartolini, D
(2016) Glutathione depletion, pentose phosphate pathway activation, and hemolysis in erythrocytes protecting cancer cells from vitamin C-induced oxidative stress, J
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