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Alcohol 61:915 Fernndez-Sol J, Riba RE (2017) J Alcohol Drug Depend Alpert MA (2001) Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

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They are chemically distinct: copper binding alters charge, conformation, and the chemistry researchers are usually probing, so the two are not interchangeable in experimental design