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Graphical Abstract Similar content being viewed by others Introduction Obesity is an escalating global health issue

Findings Participants and Intervention: Between October 5, 2018, and February 1, 2019, 304 individuals were randomly assigned to either receive semaglutide 2.4 mg (n = 152) or placebo (n = 152) and were encompassed in the comprehensive analysis set (comprising all randomized individuals as per the intention-to-treat principle)

Kanbak, Age-related changes in the glutathione redox system, Cell Biochem

Surgery: Indicated for complete structural tears but involves prolonged recovery, scar tissue formation, and variable long-term outcomes in chronic cases

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The best outcomes happen when medication is paired with structured lifestyle support