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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials

Common reasons for stopping include achievement of weight goals, intolerable side effects, cost or access issues, pregnancy planning, or patient preference

These lifestyle changes are not just adjuncts to medication but form the bedrock of sustainable weight loss and improved well-being during this life stage

The SPF mice exhibited decreased locomotor activity in the Ex-4-injected group (Fig

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