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Gadelha, M
Tryptophan oxidation is the degradation route most commonly detected by RP-HPLC in stored melanocortin analogues, with tyrosine at position 2 and histidine at position 6 secondary sites of concern, and freeze-thaw cycling accelerates both aggregation and oxidative degradation
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Signs of dehydration Signs you may be dehydrated include: altered mental status or poor concentration fatigue low urine output darker-colored urine dry skin and cracked lips decreased skin elasticity headaches dizziness or lightheadedness heart palpitations low blood pressure Thompson: There are simple steps patients can take to mitigate dehydration while taking GLP-1 medications during a heatwave
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