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In medical settings it is usually diluted in normal saline and infused slowly into a vein, with a typical loading dose of 50 mg per kilogram over two to three minutes followed by maintenance doses every six hours or by continuous infusion

People Starting Treatment: New users may experience temporary effects while adjusting to treatment

Results may be visible for several weeks, though consistent sessions are needed for permanent whitening

One review notes that while berberine may have some promise, its not proven to safely or consistently raise GLP-1 in people, and higher-quality research needs to be performed