Statements Author contributions HuZ: Validation, Investigation, Conceptualization, Writing review & editing, Software, Writing original draft, Visualization
Neither involves copper metabolism, making them suitable for those with copper sensitivity
364 The affected astrocytes demonstrate profound loss of function, in particular impaired K + buffering, 365,366 compromised H + transport, 367 and substantial decrease in glutamate uptake
Whilst vitamin B12 side effects stomach-related are uncommon, some individuals experience mild gastrointestinal symptoms when taking supplements, particularly oral formulations
Supplements like CLA and L-carnitine are attractive because they are widely available and have plausible roles in fat handling
While L-carnitine does not contribute to enhancing VPA clearance, its impact on accelerating blood lactate level normalization and/or preventing organ dysfunction remains uncertain