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Metabolomics data are provided in the Supplementary Tables 3, 4
Tirzepatide at therapeutic doses (10-15 mg) produces enough appetite suppression and weight loss that adding a stimulant provides minimal additional benefit while introducing unnecessary risks
Saxenda costs According to the company that makes Saxenda, Novo Nordisk, the list price is $1,350 for a 1-month supply
In a phase 2 clinical trial targeting obese individuals without type 2 diabetes (T2D), retatrutide dosed at 1 to 12 mg resulted in up to 24.2% weight loss over a 48-week treatment period, compared to 2.1% in the placebo group, and demonstrated a dose-dependent effect
Nephrol Dial Transplant 38(9):20412051 Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R et al (2023) Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
