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Weight loss typically becomes measurable (12 pounds per week) after 24 weeks of consistent dosing
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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH
It also plays a role in maintaining antioxidant levels overnight
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