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For superoxide anion, the main ROS, a first line of defense is represented by the enzyme superoxide dismutase, localized in the mitochondrial matrix
& Abramov, A
Lilly, E
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Interestingly, a role for UCP2 in the transport of mGSH has been described in neurons, suggesting that the transport of protons back into the matrix by UCP2 may favor the movement of GSH ( MITOCHONDRIAL MEMBRANE PROPERTIES AND IMPACT ON GLUTATHIONE IMPORT Previous studies in liver mitochondria have revealed that membrane dynamics regulate the transport of mGSH
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