The peptide is structurally derived from native human GLP-1(7-37) with two amino acid substitutions (Aib at position 8 for DPP-IV resistance, Arg substitution at position 34) and a C18 fatty diacid moiety conjugated via a Glu-(AEEA) linker enabling reversible albumin binding and an extended pharmacokinetic profile compatible with once-weekly dosing
The reality: These medications are expensive to research, manufacture, and test Insurance coverage is limited or nonexistent for many patients In some cases, a compounding pharmacy may offer customized alternatives when medically appropriatesuch as different doses or formulations for patients with sensitivities
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Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
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