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Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness
This implies that it might be insufficient to treat deficiency through oral supplements as they were never absorbed correctly
Increased methionine One of the nutrients used in lipotropic injections is methionine, which has several benefits
Ipamorelin appears to ease that brake during a short window
S., Gabbay, R
10.1186/s12951-022-01477-8 190
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