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The primary endpoints were the superiority of tirzepatide over placebo in terms of weight change at 52 weeks and the proportion of patients achieving a weight loss of 5%

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"Maintenance" doesn't mean the drug stops working it means you've found the dose where you're losing weight (or maintaining loss) without intolerable side effects

Elevated insulin resistance measured through fasting insulin and HOMA-IR also points toward careful escalation, while a lower baseline BMI may call for lower targets

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