Plateaus are common during weight loss because as you lose fat or muscle, your metabolism can slow down a bit, meaning you burn fewer calories at rest
Cyclisation in Melanotan II flattens that profile, giving comparable potency at MC1R and MC4R and only modestly less at MC3R and MC5R, which is why Melanotan II is used as the non-selective positive control while Melanotan 1 is used where an MC1R-weighted reference agonist is wanted
That is a meaningful concern
Talk with your prescribing provider, OB-GYN, or primary care clinician

According to the safety information, seek immediate medical care if you experience: Pancreatitis symptoms: Severe abdominal pain that doesn't go away, with or without vomiting Pain that radiates to your back Gallbladder problems: Severe abdominal pain, particularly in the upper right area Yellowing of skin or eyes (jaundice) Clay-colored stools Fever with abdominal pain Severe allergic reactions: Swelling of face, lips, tongue, or throat Difficulty breathing or swallowing Rapid heartbeat Severe rash or hives Kidney problems: Significantly decreased urination Swelling in legs or ankles Unusual fatigue or confusion Thyroid symptoms: Lump or swelling in the neck Hoarseness that doesn't improve Difficulty swallowing Shortness of breath Mental health changes: New or worsening depression Unusual mood changes Thoughts of self-harm According to the safety information, GLP-1 medications carry a boxed warning about thyroid C-cell tumors

Sleeping through the peak effect period means waking up already past the worst of any symptoms