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Although an increased risk of pancreatitis is listed in product monographs for GLP-1RAs and caution should be exercised in individuals with a history of pancreatitis, causality has not been established [4, 66]
The direct-start group experienced nearly double the rate of GI adverse events
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Unlike drugs such as corticosteroids or certain antidepressants, there is no official tapering protocol for tirzepatide
Patients with renal impairment require particular caution with metformin, as reduced kidney function increases the risk of lactic acidosis, a rare but serious complication
51%-55% of those on tirzepatide achieved at least one stage of fibrosis improvement without worsening of MASH compared with 30% on placebo
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