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In placebo-controlled trials, severe GI reactions were reported in 1.7% (5 mg), 2.5% (10 mg), and 3.1% (15 mg) of Zepbound-treated patients compared to 1% of placebo-treated patients
More common: poor injection timing (60+ minutes post-workout), inadequate training intensity (receptors werent upregulated), counterfeit product, insufficient protein intake (0.8g per lb minimum), or injecting on rest days
For cagrilintide , Phase 2 data has shown meaningful weight loss when used as monotherapy, and the CagriSema combination (cagrilintide plus semaglutide) has entered Phase 3 trials under the REDEFINE programme by Novo Nordisk
1 Diarrhoea and constipation were also more common on retatrutide than on placebo
Greco EV, Russo G, Giandalia A, et al
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