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These drugs fall within two categories: human GLP-1 backbone agents (that is, albiglutide, dulaglutide, liraglutide and semaglutide) and exendin-4 backbone agents (that is, exenatide, lixisenatide and tirzepatidethe latter activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors) 1
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
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Slow titration minimizes these effects while allowing the body to adjust
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