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If tiredness is persistent, the safer approach is to look for the cause, because low energy can result from sleep problems, anemia, thyroid disorders, depression, infection, or heart disease

doi: 10.1186/s12915-015-0193-6 20 FauvarqueM

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This trial enrolled adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, and assessed multiple doses of retatrutide against placebo over 48 weeks