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Dose reductions are underutilized

Conjugation of GSH with electrophilic compounds is mainly mediated by the glutathione- S -transferases (GSTs), a super family of Phase II detoxification enzymes

We also evaluated whether GLP-1R and PKA signalling were involved in the protective effect of metformin in HUVECs

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Post-treatment catch-up was modeled to return risk factors toward baseline or toward their natural trajectory under D&E, consistent with established COM precedents ( Table 2 )