Dose escalation can be delayed by 1 week or altered to a more gradual dose escalation if GI intolerance is continued [12, 87], as extending time between dose escalations can help mitigate tolerability issues
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Therefore, we hypothesize that the benefits of semaglutide can be extended to patients with these cognitive impairments, but more clinical studies are needed in the future to further confirm this
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With regards to specific outcomes such as HF, there has been heterogeneity in the results with both GLP-1RAs and DPP-4i
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