Nausea is the most common side-effect GLP-1 symptom, followed by vomiting, sour burps, heartburn and gastroparesis Side-Effect Profile of GLP-1s, from Worst to Best (% reflects estimated number of patients with GI side-effects) 50% Semaglutide (Ozempic, Rybelsus, Wegovy) 40% Tirzepatide (Saxenda, Mounjaro) 40% Liraglutide (Victoza, Saxenda) 30% Lixisenatide (Adlyxin USA, Lyxumia UK) 10% Dulaglutide (Trulicity) 10% Exenatide (Byetta, Bydureon) Wegovy, Mounjaro, and Saxenda FDA-approved for weight loss
Doses are adjusted by healthcare providers depending on medical condition, body weight, and treatment objectives
Altered NAD availability also affects sirtuin expression and activity in UV-exposed human skin cells
Neither CJC-1295 without DAC nor ipamorelin is FDA-approved for any indication, and the combination has no regulatory approval
PMCID: PMC7447324
Excessive Vitamin B6 can cause nerve damage, while excess Vitamin B12 is typically excreted in urine