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The reduction in liver fat results from pleiotropic actions of FGF21, particularly suppressing caloric burden in the liver, reducing de novo lipogenesis, and increasing fat oxidation in the liver

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This reduction is associated with slower healing, reduced skin elasticity, and changes in hair and tissue quality

To address this, integrative studies that explore multilayer interactions between different biological elements are highly encouraged [50, 51]

(2001) Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C