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Notably, the clinical application of GLP-1RAs has gradually expanded beyond its original scope

Meanwhile, other studies demonstrate a reduction in compulsive behaviors like drinking and gambling

While semaglutide and tirzepatide are currently FDAapproved options within this category, additional peptide therapies such as retatrutide are in advanced clinical trials

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All ChIP signals were normalized to the input (labeled as % of input on the vertical axis)

In the Phase III FLOW trial, Novo demonstrated that T2D patients taking semaglutide were 24% less likely to develop the studys primary composite outcome of kidney failure onset, reduced kidney function and kidney-related or cardiovascular death