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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

The better your glutathione levels, the more effectively you will detox bad estrogen metabolites and reduce inflammation in the uterus, endometrium, and ovaries

These effects typically emerge during dose initiation or escalation and often diminish over time as the body adjusts to the medication

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MOTS-C in particular degrades more rapidly than many other peptides once reconstituted