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Nutrients , 12(7), 1925

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Knowing your prescription, learning to give yourself shots, and keeping an eye on how youre doing helps manage your vitamin B12 therapy

A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

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CDC summarizes USP guidance: date an opened multi-dose vial at first puncture and discard it within 28 days unless the manufacturer states another opened-vial date. The dose count and 28-day window together require three vials for the 12-week protocol