Yes, these drugs were originally developed for type 2 diabetes but are now widely used for weight management because they reliably reduce appetite and induce significant weight loss
One 2022 review of studies in Frontiers in Nutrition on berberine supplementation for adults with cardiovascular disease risk found that supplementing it reduced weight and body mass index (BMI), as well as other metrics like cholesterol and blood pressure
PT-141 takes a different route
Sulforaphane helps turn on the bodys own built-in detox machinery by activating the Nrf2 pathway, which boosts production of powerful phase II detoxification that convert fat-soluble pollutants into water-soluble forms for excretion, allowing the body to more efficiently eliminate toxins, heavy metals, pesticide residues, and other environmental chemicals
doi: 10.1016/j.jsbmb.2015.09.003 143 Luque-RamirezMAlvarez-BlascoFAlpanesMEscobar-MorrealeHF
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