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Mild nausea or a temporary drop in blood pressure

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42 Metformin interferes with oxidative phosphorylation in mitochondria and stimulates osteogenic differentiation via AMPK, which is known to promote osteogenic and suppress adipogenic differentiation, although the exact mechanism of this action is unknown

Diabetes can damage nerves directly through years of raised blood sugar, and Diabetes UK explains that this diabetic neuropathy most often shows up in the feet as numbness, tingling or burning pain